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Tag: nanoparticles

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ACCEPTED PAPER! Encapsulation of VEGF165 in magnetic PLGA nanocapsules

 

Encapsulation of VEGF165 in magnetic PLGA nanocapsules for potential local delivery and bioactivity into human brain endothelial cells

 

Elisa Carenza, Olivier Jordan, Pablo San Segundo Martínez, Radovan Jiřík, Zenon Starčuk jr., Gerrit Borchard, Anna Rosell* and Anna Roig*  

 

 J. Mater. Chem. B, 2015, 

 Accepted Manuscript 
 DOI: 10.1039/C4TB01895H
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New drug delivery systems based on biodegradable magnetic nanocapsules for targeted delivery of pro-angiogenic proteins, potentially useful in therapeutic angiogenesis. 

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Hot off the press! New publication in Chem. Commun.

Crystallization of hollow mesoporous silica nanoparticles

Glenna L. Drisko, Adrian Carretero-Genevrier, Alexandre Perrot, Martí
Gich, Jaume Gàzquez, Juan Rodriguez-Carvajal, Luc Favre, David Grosso,
Cédric Boissière,  Clément Sanchez

ChemComm, DOI: 10.1039/x0xx00000x

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Complex 3D nacrostructured nanoparticles are  transformed from amorphous silica into pure polycrystalline α-quartz using catalytic quantities of  alkaline earths as devitrificants. Walls as thin as 10 nm could be crystallized without losing the architecture of the particles. The roles of cation size and the mol% of  incorporated devitrificant on crystallization behavior are studied, with Mg2+, Ca2+, Sr2+ and Ba2+  allproducing pure α-quartz under certain conditions.

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FRIDAY 14th, PhD DEFENSE of NEREA MURILLO

Nerea Murillo-Cremaes will defend her PhD thesis entitled:

MULTIFUNCTIONAL SILICA-BASED NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

The thesis has been supervised by Dr. Concha Domingo and Dr. Anna Roig.

The thesis jury will be formed by Prof Daniel Ruiz-Molina, Institut Català de Nanociencia i Nanotecnologia, Nanosfun Group, Bellaterra, Catalonia, Prof Vadim Kessler, Swedish University of Agricultural Sciences, Department of Chemistry and Biotechnology, Sweden and  Prof Julio San Román, Biomaterials Group, Instituto de Ciencia y Tecnologia de Polimeros (CSIC), Madrid, Spain

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 This thesis aimed to fabricate hybrid (organic-inorganic) complex materials as drug carriers  using supercritical fluids. For that purpose, two main objectives have been addressed: first, evaluation of the potentiality of porous silica-based materials synthesized without using porogenic agents as drug delivery systems; and second, exploiting the utility of SCFs in the synthesis and functionalization of those materials. During the realization of this work, silica-based nanostructured materials have been synthesized, loaded with a model drug, physical and chemically modified on their surface, and their interaction with relevant biological entities and media were investigated.

 

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Hot off the press: new article in Journal of Polymer Science

A novel solventless coating method to graft low molecular weight polyethyleneimine on silica
fine powders
 Nerea Murillo-Cremaes, Pedro López-Aranguren, Lourdes F. Vega, Javier Saurina,
Anna Roig*, Concepción Domingo*
 Journal of Polymer Science, Part A: Polymer Chemistry (2014), on-line July DOI:10.1002/pola.27297

 

 

alt       A ring-opening polymerization process catalyzed by compressed CO2 at low pressure and temperature and in the absence of any organic solvent is presented. Fabrication of hybrid materials involving two types of silica nanoparticles (one of them with a magnetic core) coated with hyperbranched polyethyleneimine of low molecular weight was succesfully achieved. Properties of  the obtained materials are identified as excellent for some biomedical applications 

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Siming Yu gave a presentation at IDS-FunMat in Belgium.

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 IDS-FunMat is an EMMI International Doctoral School for Functional Materials, supported by ERASMUS MUNDUS.

http://www.emmi-materials.eu/

The fourth Training School took place on 16-21 March in Spa, Belgium where a number of high-profile external speakers were invited. Siming gave a presentation on the stability of nanoparticles in biological media which is part of his PhD thesis.

Project funded by the Plan Nacional de Investigación Científica!

Our application to the Fundamental Research Projects of the Spanish VI “Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica” with the project “Advanced preparation techniques for nanoparticles and their biomedical and environmental assessment (AdvancedNP)” has been funded.

We are very happy given the strong competition of the call due to the budgetary cuts.