Our paper “Nanorods based on mesoporous silica containing iron oxide nanoparticles as catalytic nanomotors: study of motion dynamics” has been published in ChemNanoMat. It is a result of a collaboration of N&N Group and Smart Nano-Bio-Devices group at the Bioengineering Institute of Catalonia (IBEC).
A paper authored by Martí Gich, “Unconventional Ferroelectric Switching via Local Domain Wall Motion in Multiferroic ε‐Fe2O3 Films“, was recently published in open access in Advanced Electronic Materials. It is a result of a collaboration between scientists from ICMAB, Aalto University and Forschungszentrum Jülich. It has received funding from the ERC.
Congratulations Martí!
The paper “Micro/Nanostructure Engineering of Epitaxial Piezoelectric alpha-quartz Thin Films on Silicon” has been recently published in the journal ACS Applied Materials & Interfaces.
Congratulations to Martí Gich and former N&N Group member Qianzhe Zhang, authors of this work!
This study has been carried out in collaboration with NanoChemLab from Montpellier, France.
The paper “Tailoring the crystal growth of quartz on silicon for patterning epitaxial piezoelectric films” has been recently published in the journal Nanoscale Advances.
This study has been carried out in collaboration with NanoChemLab from Montpellier, France. Congratulations to Qianzhe Zhang and Martí Gich for being authors of this work!
Last 11th January 2019 the paper “Enhancing the localized pesticide action through the plant foliage withsilver-cellulose hybrid patches” was published on the journal ACS Biomaterials Science & Engineering.
The paper entitled “Nanoclusters of crystallographically aligned nanoparticles for magnetic thermotherapy: aqueous ferrofluid, agarose phantoms and ex vivo melanoma tumour assessment” has recently been published on the Nanoscale Journal. We congratulate Anna Roig and our collaborator Marcela Fernández for being authors of this nice study!
Abstract: Magnetic hyperthermia is an oncological therapy where magnetic nanostructures, under a radiofrequency field, act as heat transducers increasing tumour temperature and killing cancerous cells. Nanostructure heating efficiency depends both on the field conditions and on the nanostructure properties and mobility inside the tumour. Such nanostructures are often incorrectly bench-marketed in the colloidal state and using field settings far off from the recommended therapeutic values. Here, we prepared nanoclusters composed of iron oxide magnetite nanoparticles crystallographically aligned and their specific absorption rate (SAR) values were calorimetrically determined in physiological fluids, agarose-gel-phantoms and ex vivo tumours extracted from mice challenged with B16-F0 melanoma cells. A portable, multipurpose applicator using medical field settings; 100 kHz and 9.3 kA m−1, was developed and the results were fully analysed in terms of nanoclusters’ structural and magnetic properties. A careful evaluation of the nanoclusters’ heating capacity in the three milieus clearly indicates that the SAR values of fluid suspensions or agarose-gel-phantoms are not adequate to predict the real tissue temperature increase or the dosage needed to heat a tumour. Our results show that besides nanostructure mobility, perfusion and local thermoregulation, the nanostructure distribution inside the tumour plays a key role in effective heating. A suppression of the magnetic material effective heating efficiency appears in tumour tissue. In fact, dosage had to be increased considerably, from the SAR values predicted from fluid or agarose, to achieve the desired temperature increase. These results represent an important contribution towards the design of more efficient nanostructures and towards the clinical translation of hyperthermia.
We are happy to announce that last 1st of November 2018, the paper “Stability and nature of the volume collapse of ε-Fe2O3 under extreme conditions” was published on the journal Nature Communications. This study is co-authored by the permanent researcher at the N&N group Martí Gich.
Abstract: Iron oxides are among the major constituents of the deep Earth’s interior. Among them, the epsilon phase of Fe2O3 is one of the less studied polymorphs and there is a lack of information about its structural, electronic and magnetic transformations at extreme conditions. Here we report the precise determination of its equation of state and a deep analysis of the evolution of the polyhedral units under compression, thanks to the agreement between our experiments and ab-initio simulations. Our results indicate that this material, with remarkable magnetic properties, is stable at pressures up to 27 GPa. Above 27 GPa, a volume collapse has been observed and ascribed to a change of the local environment of the tetrahedrally coordinated iron towards an octahedral coordination, finding evidence for a different iron oxide polymorph. DOI: https://doi.org/10.1038/s41467-018-06966-9
Congratulations Martí!
Congratulations to Anna Laromaine, Anna Roig and their collaborators from the Karlsruhe Institute of Technology Tina Tronser (first author) and Pavel A. Levkin for their new paper: Bacterial Cellulose Promotes Long-Term Stemness of mESC! This manuscript was published on ACS Applied Materials and Interfaces the 20th of April 2018.
Abstract: Stem cells possess unique properties, such as the ability to self-renew and the potential to differentiate into an organism’s various cell types. These make them highly valuable in regenerative medicine and tissue engineering. Their properties are precisely regulated in vivo through complex mechanisms that include multiple cues arising from the cell interaction with the surrounding extracellular matrix, neighboring cells, and soluble factors. Although much research effort has focused on developing systems and materials that mimic this complex microenvironment, the controlled regulation of differentiation and maintenance of stemness in vitro remains elusive. In this work, we demonstrate, for the first time, that the nanofibrous bacterial cellulose (BC) membrane derived from Komagataeibacter xylinus can inhibit the differentiation of mouse embryonic stem cells (mESC) under long-term conditions (17 days), improving their mouse embryonic fibroblast (MEF)-free cultivation in comparison to the MEF-supported conventional culture. The maintained cells’ pluripotency was confirmed by the mESCs’ ability to differentiate into the three germ layers (endo-, meso-, and ectoderm) after having been cultured on the BC membrane for 6 days. In addition, the culturing of mESCs on flexible, free-standing BC membranes enables the quick and facile manipulation and transfer of stem cells between culture dishes, both of which significantly facilitate the use of stem cells in routine culture and various applications. To investigate the influence of the structural and topographical properties of the cellulose on stem cell differentiation, we used the cellulose membranes differing in membrane thickness, porosity, and surface roughness. This work identifies bacterial cellulose as a novel convenient and flexible membrane material enabling long-term maintenance of mESCs’ stemness and significantly facilitating the handling and culturing of stem cells.
Congratulations to the authors: Anna Laromaine, Tina Tronser, Ivana Pini, Sebastià Parets, Pavel A. Levkin and Anna Roig for their new publication on Soft Matter. The paper entitled “Free-standing three-dimensional hollow bacterial cellulose structures with controlled geometry via patterned superhydrophobic–hydrophilic surfaces” was published on the 17th of April 2018.
Abstract
Bacteria can produce cellulose, one of the most abundant biopolymer on earth, and it emerges as an interesting candidate to fabricate advanced materials. Cellulose produced by Komagataeibacter Xylinus a bacterial strain, is a pure water insoluble biopolymer, without hemicelluloses or lignin. Bacterial cellulose (BC) exhibits a nanofibrous porous network microstructure with high strength, low density and high biocompatibility and it has been proposed as a cell scaffold and wound healing material. The formation of three dimensional (3D) cellulose self-standing structures is not simple. It either involves complex multi-step synthetic procedures or uses chemical methods to dissolve the cellulose and remold it. Here we present an in situ single-step method to produce self-standing 3D-BC structures with controllable wall thickness, size and geometry in a reproducible manner. Parameters such as hydrophobicity of the surfaces, volume of the inoculum and time of culture define the resulting 3D-BC structures. Hollow spheres and convex domes can be easily obtained by changing the surface wettability where the BC grows. The potential of these structures as a 3D cell scaffold is exemplified supporting the growth of mouse embryonic stem cells within a hollow spherical BC structure, indicating its biocompatibility and future prospective.
New publication from the N&N group in collaboration with the Universitat Politècnica de Catalunya!
Congratulations to all the authors of the manuscript and especially to Miquel Torras (Ph.D. student at the N&N group) and Pol Sallés (previous researcher at the N&N group) for the first publication of their careers! The paper “Fast and Simple Microwave Synthesis of TiO2/Au Nanoparticles for Gas-Phase Photocatalytic Hydrogen Generation” has been published on April 12th 2018 at the open access journal Frontiers in Chemistry.
Abstract: The fabrication of small anatase titanium dioxide (TiO2) nanoparticles (NPs) attached to larger anisotropic gold (Au) morphologies by a very fast and simple two-step microwave-assisted synthesis is presented. The TiO2/Au NPs are synthesized using polyvinylpyrrolidone (PVP) as reducing, capping and stabilizing agent through a polyol approach. To optimize the contact between the titania and the gold and facilitate electron transfer, the PVP is removed by calcination at mild temperatures. The nanocatalysts activity is then evaluated in the photocatalytic production of hydrogen from water/ethanol mixtures in gas-phase at ambient temperature. A maximum value of 5.3 mmol·g−1cat⋅gcat-1·h−1 (7.4 mmol·g−1TiO2⋅gTiO2-1·h−1) of hydrogen is recorded for the system with larger gold particles at an optimum calcination temperature of 450°C. Herein we demonstrate that TiO2-based photocatalysts with high Au loading and large Au particle size (≈50 nm) NPs have photocatalytic activity.
The N&N group participates in the @NextGEM_eu project, for which we prepared this video explaining how we work with c.elegans. 🪱
👉 Dr. @PolAlonso1 explains how we use these nematodes and why they are useful for assessing biological effects.
#BioEM #5G
We are thrilled to announce that Dr. @AnnaRoig8 from the @NNgroupICMAB research group (@icmabCSIC, Barcelona, Spain) will be offering a talk on "Opportunities of bacterial nanocellulose in healthcare". This Wednesday at 12.15h at the BBT Weekly Meetings, at @EEBE_UPC
