The paper “Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer” has been published in Chemical Engineering Journal. The paper is co-authored by Anna Roig and a former N&N Group member Siming Yu (now Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development, Guangzhou).
The article “Anticipating hyperthermia efficiency of magnetic colloids by a semi-empirical model: a tool to help medical decisions” (DOI: 10.1039/C6CP08059F and is now available online.
This paper is the result of a collaboration with the Instituto de Física La Plata (IFLP- CONICET) at the Universidad Nacional de La Plata (UNLP) in Argentina.
Congratulations!
Abstract:
Magnetic hyperthermia, a modality that uses radio frequency heating assisted with single-domain magnetic nanoparticles, is becoming established as a powerful oncological therapy. Much improvement in nanomateriales development, to enhance their heating efficiency by tuning the magnetic colloids properties, has been achieved.
However, methodological standardization to accurately and univocally determine the colloids properties required to numerically reproduce specific heating efficiency using analytical expressions still holds.Thus, anticipating the hyperthermic performances of magnetic colloids entails high complexity due to polydispersity, aggregation and dipolar interaction always present in real materials to a more or lesser degree.
Here, by numerically simulating experimental results and using real biomedical aqueous colloids, we analyse and compared several approaches to reproduce experimental specific absorption rate values. Then, we show that relaxation time, determined using a representative mean activation energy consistently derived from four independent experiments accurately reproduces experimental heating efficiencies.
Moreover, the so-derived relaxation time can be used to extrapolate the heating performance of the magnetic nanoparticles to other field conditions within the framework of the linear response theory. We thus present a practical tool that may truly aid the design of medical decisions.
n&n group members would like to congratulate Siming for his good work on the PhD defense.
Si-Ming Yu will defend her PhD thesis entitled:
Microwave synthesis of inorganic nanocrystals and their evaluation in biological environments
The thesis has been supervised by Dr. Anna Laromaine and Dr. Anna Roig
IDS-FunMat is an EMMI International Doctoral School for Functional Materials, supported by ERASMUS MUNDUS.
http://www.emmi-materials.eu/
The fourth Training School took place on 16-21 March in Spa, Belgium where a number of high-profile external speakers were invited. Siming gave a presentation on the stability of nanoparticles in biological media which is part of his PhD thesis.
The N&N group participates in the @NextGEM_eu project, for which we prepared this video explaining how we work with c.elegans. 🪱
👉 Dr. @PolAlonso1 explains how we use these nematodes and why they are useful for assessing biological effects.
#BioEM #5G
We are thrilled to announce that Dr. @AnnaRoig8 from the @NNgroupICMAB research group (@icmabCSIC, Barcelona, Spain) will be offering a talk on "Opportunities of bacterial nanocellulose in healthcare". This Wednesday at 12.15h at the BBT Weekly Meetings, at @EEBE_UPC
