New article: Tracking Silica Microparticles in Mice
NN researchers Jan Grzelak, Martí Gich, Anna Roig and Juan Pellico have published a new article in the journal Dalton Trans. The study has been carried out in close collaboration with Rafael T. M. Rosales, from the King's College London.
The study reveals that microparticles with similar size but different shapes do not travel through the body in the same manner. By using PET imaging, this NN-led team discovered that rod-shaped microparticles exit the bloodstream more quickly and concentrate in more in the lungs than spherical particles that primarily accumulate in the liver and spleen. This shape-dependent behaviour could guide the design of new drug delivery systems.
Title
DOI: 10.1039/D5DT00412H
Abstract
Particles at the nanometric–micrometric interface hold promise by combining the drug-loading capacity of microparticles with the systemic benefits of nanoparticles. We assess the in vivo behaviour in mice via PET imaging of silica rods and spheres (∼1 μm), showing different biodistributions thus highlighting the potential for shape-dependent targeting.
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